Cardio-Metabolic Syndrome

Therese Conlon-Barratt
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C.M.S

Cardio-metabolic syndrome is a combination of metabolic dysfunctions characterised by insulin resistance (too much glucose in the blood), hypertension, high cholesterol, central adiposity, obesity and type 2 diabetes.

It’s prevalence has been steadily increasing worldwide now affecting up to 38.5% of western populations and 1 in 4 adults in the UK, putting them at risk of heart disease and other cardiovascular problems. Unfortunately, a lot of people are unaware if it’s presence with some only finding out during a routine appointment. Therefore I believe prevention is key in tackling this condition before the progression of symptoms.

In the UK diagnosis is regarded as having 3 or more of the following symptoms:

C.M.S

Cardio-metabolic syndrome is a combination of metabolic dysfunctions characterised by Insulin resistance (too much glucose in the blood), hypertension, high cholesterol, central adiposity, obesity and type 2 diabetes.

Its prevalence has been steadily increasing worldwide now affecting up to 38.5% of western populations and 1 in 4 adults in the UK, putting them at risk of heart disease and other cardiovascular problems. Unfortunately, a lot of people are unaware if it’s presence with some only finding out during a routine appointment. Therefore I believe prevention is key in tackling this condition before the progression of symptoms.

In the UK diagnosis is regarded as having 3 or more of the following symptoms:

  • A waist circumference of 94cm (37 inches) or more in European men, or 90cm (35.5 inches) or more in South Asian men.

  • A waist circumference of 80cm (31.5 inches) or more in European and South Asian women

  • High triglyceride levels and low levels of HDL (‘good’ cholesterol) in the blood, which can lead to atherosclerosis (where arteries become clogged up by fatty substances such as cholesterol)

  • High blood pressure that’s consistently 140/90mmHg or higher.

  • Inability to control blood sugar levels (insulin resistance) 

  • Increased risk of developing blood clots, such as deep vein thrombosis (DVT).  

  • A tendency to develop inflammation (irritation and swelling of body tissue)

Other conditions related to cardiometabolic syndrome are PCOS polycystic ovary syndrome and NAFLD Non-alcoholic fatty liver disease. (1)

Interesting recent clinical trials identified genetic associations with metabolic syndrome specifically from lipid metabolic pathways, while advanced research is continually finding increased gene associations relating to other metabolic symptoms. (2,3)

Futhermore accumulating evidence suggests that an imbalance of gut microbiome  can play a significant role in the initiation and progression of metabolic syndrome. A diverse microbiome is proven to modulate blood glucose, appetite, lipids profiles and pro-inflammation. In addition, prebiotics or probiotics, which have proven to manipulate our microbiome, may help to reduce intestinal inflammation and improve digestive health which in turn may reduce blood glucose and lipid levels, induce weight loss and decrease insulin resistance. (4)

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